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Fensartan (Losartan)
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Fensartan

Fensartan is used to treat hypertension, left ventricular hypertrophy (increase in muscle) and diabetic nephropathy. It's an orally active angiotensin II receptor antagonist. Fensartan is hypotension medication which specifically blocks angiotensin II receptors, decreases the total peripheral resistance, concentration of aldosteron in blood, arterial pressure, pressure in pulmonary circulation, and has a diuretic effect.

Other names for this medication:
Angibloc, Angilock, Angioten, Biortan, Cardon, Cormac, Giovax, Hypozar, Lakea, Loctenk, Lohyp, Lopernal, Lopress, Lorista, Lortaan, Losacor, Losan, Losaprex, Losazid, Lostad, Maxartan, Nefrotal, Omnitan, Ozarium, Rasoltan, Resilo, Sedeten, Simperten, Sortiva, Temisartan

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Also known as: Losartan

Description

Fensartan (losartan potassium) is an angiotensin II receptor blocker acting on the AT1 receptor subtype. Losartan potassium, a non-peptide molecule, is chemically described as 2-butyl-4-chloro-1-[p-(o-1Htetrazol- 5-ylphenyl)benzyl]imidazole-5-methanol monopotassium salt.

Fensartan is a white to off-white free-flowing crystalline powder with a molecular weight of 461.01. It is freely soluble in water, soluble in alcohols, and slightly soluble in common organic solvents, such as acetonitrile and methyl ethyl ketone. Oxidation of the 5-hydroxymethyl group on the imidazole ring results in the active metabolite of losartan.

Fensartan is available as tablets for oral administration containing either 25 mg, 50 mg or 100 mg of losartan potassium and the following inactive ingredients: microcrystalline cellulose, lactose hydrous, pregelatinized starch, magnesium stearate, hydroxypropyl cellulose, hypromellose, and titanium dioxide.

Fensartan 25 mg, 50 mg and 100 mg tablets contain potassium in the following amounts: 2.12 mg (0.054 mEq), 4.24 mg (0.108 mEq) and 8.48 mg (0.216 mEq), respectively. Fensartan 25 mg, Fensartan 50 mg, and Fensartan 100 mg may also contain carnauba wax.

Dosage

Usual Adult Dose for Diabetic Nephropathy:

Initial dose: 50 mg orally once a day Maximum dose: 100 mg orally once a day Comments: -If hypertensive patients with left ventricular hypertrophy or type 2 diabetic nephropathy patients require titration from initial dose, increase to 100 mg orally once a day. -Antihypertension is substantially present within 1 week but in some studies the maximal effect occurred in 3 to 6 weeks. Uses: -Treatment of hypertension. -To reduce the risk of stroke in patients with hypertension and left ventricular hypertrophy. -Treatment of diabetic nephropathy with an elevated serum creatinine and proteinuria (urinary albumin to creatinine ratio 300 mg/g or greater) in patients with type 2 diabetes and a history of hypertension.

Usual Adult Dose for Hypertension:

Initial dose: 50 mg orally once a day Maximum dose: 100 mg orally once a day Comments: -If hypertensive patients with left ventricular hypertrophy or type 2 diabetic nephropathy patients require titration from initial dose, increase to 100 mg orally once a day. -Antihypertension is substantially present within 1 week but in some studies the maximal effect occurred in 3 to 6 weeks. Uses: -Treatment of hypertension. -To reduce the risk of stroke in patients with hypertension and left ventricular hypertrophy. -Treatment of diabetic nephropathy with an elevated serum creatinine and proteinuria (urinary albumin to creatinine ratio 300 mg/g or greater) in patients with type 2 diabetes and a history of hypertension.

Usual Pediatric Dose for Hypertension:

6 Years or Older: Initial dose: 0.7 mg/kg orally once a day (up to 50 mg total) Comments: -May be given as a tablet or suspension. -Doses above 1.4 mg/kg (or 100 mg) daily have not been studied in pediatric patients.

Detailed Fensartan dosage information

Overdose

If you overdose Fensartan and you don't feel good you should visit your doctor or health care provider immediately. Symptoms of Fensartan overdosage: fainting, feeling lightheaded, rapid heartbeat.

Storage

Store at room temperature between 15 and 30 degrees C (59 and 86 degrees F) away from moisture, light and heat. Keep container tightly closed. Throw away any unused medicine after the expiration date. Keep out of the reach of children in a container that small children cannot open.

Side effects

The most common side effects associated with Fensartan are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.

Contraindications

Drinking alcohol can further lower your blood pressure and may increase certain side effects of Fensartan.

Do not use potassium supplements or salt substitutes, unless your doctor has told you to.

Avoid getting up too fast from a sitting or lying position, or you may feel dizzy.

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Uniform semiclassical approach to fidelity decay in the deep Lyapunov regime. Microwave-induced high shear melt granulation was compared with conventional melt granulation performed in the same processor. The symptoms scored were urinary frequency, cystitis, bladder spasm, urinary incontinence, urinary retention, diarrhoea, haemorrhoids, proctitis, anal skin discomfort and fatigue. We compared amplification of DNA purified by silica matrix and Prep-A-gene kit. None of the other pregnancy outcomes was associated with cell phone exposure. After investigation of several different protocols, we present a less invasive metabolic test that involves IM injection of caffeine and halothane, and subsequent measurement of interstitial lactate to differentiate between MH susceptible (MHS) and MH non-susceptible (MHN) individuals. This Review highlights recent advances in evaporative assembly of confined solutions, focusing especially on recently developed approaches nizoral 200mg tablets that provide structures with unprecedented regularity composed of polymers, nanoparticles, and biomaterials, by controlled evaporation-driven, flow-aided self-assembly.

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The post-mortem Troponin-T fragmentation observed in this study reveals a sequential, time-dependent process with the potential for use as a predictor of PMI in cases of burning. This is a systematic review of the available literature and our own personal experience regarding the optimal management of the rhinoplasty patient. Factors associated with physician decision-making in starting tube feeding. A middle incision was made in a prone position under general anesthesia, and C2-C3 was fixed with interlaminal wiring according to the McGraw modified method. Since the differentiation of radial glial cells is indispensable during brain development, we hypothesize that stem cells also generate radial glial cells during in vitro neural differentiation. Patients with headache attending the Neurology Clinic, Hospital Universiti Sains Malaysia, Kelantan, Malaysia, were screened against the inclusion/exclusion criteria before recruitment. The regulation of human P450c17 activity: relationship to premature adrenarche, insulin resistance and the polycystic ovary syndrome. Analyzing the crossover from MBE to PLD, the scaling properties of the time-dependent nucleation density as well as the influence of Ehrlich-Schwoebel barriers, we find that there is indeed a range of parameters, where the surface quality in tramadol hcl 50 mg capsule untuk apa PLD is better than in MBE. However, the mechanisms underlying this ability of cathepsins are still poorly understood.

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Efficacy, tolerability and satisfaction with sildenafil citrate 100-mg titration compared with continued 50-mg dose treatment in men with erectile dysfunction. In our study, female gender was an independent predictor of in-hospital mortality in patients with IAMEST treated with PA. The comparative study on autologous bone grafts for scaphoid reconstruction revealed comparable results for both patients with and without PINN independent from the choice of bone graft. These groups are at higher risk of mental illness and demonstrate lower participation in research. Association of single nucleotide polymorphisms (SNPs) in TNF-LTA locus with breast cancer risk in Indian population. These results show that autaptic activity plays a subtle role in the synchronization of the neuronal network. In 6 domestic pigs, the cranial L4 endplate was perforated to penetrate the nucleus pulposus.

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