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Koncal (Calcitriol)
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Koncal

Koncal is in a class of medications called vitamin D analogs. Koncal comes as a capsule and a solution (liquid) to take by mouth. It works by helping the body to use more of the calcium found in foods or supplements and regulating the body's production of parathyroid hormone.

Other names for this medication:
Actical, Admax, Alcee, Alfacal, Alfacip, Alfarich, Apcical, Arachitol, Biocal, Biocitral, Bonetuf, Calasto, Calbec, Calbory, Calbovic, Calcigra, Calcikind, Calcirol, Calcitriol, Calday, Calfa, Calosto, Calotec, Calsonic, Calsure, Caltin, Caltive, Calvical, Cholical, Citroj, Devita, Duracal, Estovon, Fovit, Kurecal, Lctrol, Minroset, Novadee, Nutribone, Osteobel, Politrol, Qpcal, Rical, Riecal, Rolsical, Romical, Solbiocal, Sunmic, Zaxial

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Omnicef, Parlodel, Starlix, Ativan, Zyvox, Moximat, Desloratadine, Tramakind, Rosuvas, Sanlin, Krisp, Petin,

Also known as: Calcitriol

Description

Generic Koncal is a synthetic vitamin D analog which is active in the regulation of the absorption of calcium from the gastrointestinal tract and its utilization in the body. The two known sites of action of Generic Koncal are intestine and bone. Generic Koncal receptor-binding protein appears to exist in the mucosa of human intestine. Additional evidence suggests that Generic Koncal may also act on the kidney and the parathyroid glands. Generic Koncal is the most active known form of vitamin D3 in stimulating intestinal calcium transport. In acutely uremic rats Generic Koncal has been shown to stimulate intestinal calcium absorption. The kidneys of uremic patients cannot adequately synthesize Generic Koncal, the active hormone formed from precursor vitamin D. Resultant hypocalcemia and secondary hyperparathyroidism are a major cause of the metabolic bone disease of renal failure. However, other bone-toxic substances which accumulate in uremia (eg, aluminum) may also contribute. The beneficial effect of Generic Koncal in renal osteodystrophy appears to result from correction of hypocalcemia and secondary hyperparathyroidism. It is uncertain whether Generic Koncal produces other independent beneficial effects. Koncal is also known as Calcitriol. Generic Koncal treatment is not associated with an accelerated rate of renal function deterioration. No radiographic evidence of extraskeletal calcification has been found in predialysis patients following treatment. The duration of pharmacologic activity of a single dose of calcitriol is about 3 to 5 days. Generic name of Generic Koncal is Calcitriol. Brand name of Generic Koncal is Koncal.

Dosage

This section provides information on the proper use of a number of products that contain vitamin d and related compounds. It may not be specific to Koncal. Please read with care.

For use as a dietary supplement:

Do not take more than the recommended daily amount. Vitamin D is stored in the body, and taking too much over a period of time can cause poisoning and even death.

If you have any questions about this, check with your health care professional.

For individuals taking the oral liquid form of this dietary supplement:

This preparation should be taken by mouth even though it comes in a dropper bottle. This dietary supplement may be dropped directly into the mouth or mixed with cereal, fruit juice, or other food.

While you are taking alfacalcidol, calcifediol, calcitriol, dihydrotachysterol, doxercalciferol or paricalcitol , your health care professional may want you to follow a special diet or take a calcium supplement. Be sure to follow instructions carefully. If you are already taking a calcium supplement or any medicine containing calcium, make sure your health care professional knows.

The dose medicines in this class will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of these medicines. If your dose is different, do not change it unless your doctor tells you to do so.

The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.

For alfacalcidol To treat bone disease in kidney patients undergoing kidney dialysis: For oral dosage form (capsules): Adults and teenagers—At first, 1 microgram (mcg) a day. Your doctor may change your dose if needed. However, most people will take not more than 3 mcg a day. For oral dosage form (drops): Adults and teenagers—At first, 1 microgram (mcg) a day. Your doctor may change your dose if needed. However, most people will take not more than 3 mcg a day. For oral dosage form (solution): Adults and teenagers—At first, 1 mcg a day. Your doctor may change your dose if needed. However, most people will take not more than 3 mcg a day. For parenteral dosage form (injection): Adults and teenagers—At first, 1 mcg a day. Your doctor may change your dose if needed. However, most people will take not more than 12 mcg a week. To treat diseases in which calcium is not used properly by the body: For oral dosage form (capsules): Adults and teenagers—At first, 0.25 microgram (mcg) a day. Your doctor may change your dose if needed. However, most people will take not more than 1 mcg a day. For oral dosage form (drops): Adults and teenagers—At first, 0.25 microgram (mcg) a day. Your doctor may change your dose if needed. However, most people will take not more than 1 mcg a day. For oral dosage form (solution): Adults and teenagers—At first, 0.25 mcg a day. Your doctor may change your dose if needed. However, most people will take not more than 1 mcg a day.

For calcifediol To treat diseases in which calcium is not used properly by the body or to treat bone disease in kidney patients undergoing kidney dialysis: For oral dosage form (capsules): Adults, teenagers, and children over 10 years of age—At first, 300 to 350 micrograms (mcg) a week, taken in divided doses either once a day or every other day. Your doctor may change your dose if needed. Children 2 to 10 years of age—50 mcg a day. Children up to 2 years of age—20 to 50 mcg a day. To treat diseases in which calcium is not used properly by the body or to treat bone disease in kidney patients undergoing kidney dialysis: For oral dosage forms (capsules and solution): Adults, teenagers, and children—At first, 0.25 micrograms (mcg) a day. Your doctor may change your dose if needed. For parenteral dosage forms (injection): Adults and teenagers—At first, 0.5 mcg injected into a vein three times a week. Your doctor may change your dose if needed. Children—Use and dose must be determined by your doctor.

For dihydrotachysterol To treat diseases in which calcium is not used properly by the body: For oral dosage forms (capsules, solution, or tablets): Adults and teenagers—At first, 100 micrograms (mcg) to 2.5 milligrams (mg) a day. Your doctor may change your dose if needed. Children—At first, 1 to 5 mg a day. Your doctor may change your dose if needed.

For doxercalciferol To treat an overactive parathyroid gland in patients with kidney failure: For oral dosage form (capsules): Adults—10 micrograms (mcg) three times weekly at dialysis. The doctor may change your dose if needed. Children—Use and dose must be determined by your doctor.

For ergocalciferol The amount of vitamin D to meet normal daily recommended intakes will be different for different individuals. The following information includes only the average amounts of vitamin D. To prevent deficiency, the amount taken by mouth is based on normal daily recommended intakes: For oral dosage form (capsules): For the U.S. Adults and teenagers—5 to 10 micrograms (mcg) (200 to 400 Units) per day. Pregnant and breast-feeding females—10 mcg (400 Units) per day. Children 4 to 10 years of age—10 mcg (400 Units) per day. Children birth to 3 years of age—7.5 to 10 mcg (300 to 400 Units) per day. For Canada Adults and teenagers—2.5 to 5 mcg (100 to 200 Units) per day. Pregnant and breast-feeding females—5 to 7.5 mcg (200 to 300 Units) per day. Children 7 to 10 years of age—2.5 to 5 mcg (100 to 200 Units) per day. Children 4 to 6 years of age—5 mcg (200 Units) per day. Children birth to 3 years of age—5 to 10 mcg (200 to 400 Units) per day. To treat deficiency: Adults, teenagers, and children—Treatment dose is determined by prescriber for each individual based on severity of deficiency. To treat diseases in which calcium and phosphate are not used properly by the body: Adults and teenagers—At first, 1000 to 500,000 Units a day. The doctor may change your dose if needed. Children—At first, 1000 to 200,000 Units a day. The doctor may change your dose if needed.

For paricalcitol To treat an overactive parathyroid gland in patients with kidney failure: For oral dosage form (capsules): Adults—1 to 2 micrograms (mcg) one time per day or 2 to 4 mcg three times a week (not more often than every other day). The doctor may change your dose if needed. Children—Use and dose must be determined by your doctor. For parenteral dosage form (injection): Adults—0.04 to 0.1 micrograms (mcg) per kg no more than every other day during dialysis. The doctor may change your dose if needed. Children—Use and dose must be determined by your doctor.

Overdose

If you overdose Generic Koncal and you don't feel good you should visit your doctor or health care provider immediately.

Storage

Keep out of the reach of children.

Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing.

Do not keep outdated medicine or medicine no longer needed.

Side effects

The most common side effects associated with Koncal are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.

Contraindications

Tell your doctor if you have ever had any unusual or allergic reaction to medicines in this group or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.

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Soybean Roots Grown under Heat Stress Show Global Changes in Their Transcriptional and Proteomic Profiles. The mice exhibited significant freezing, even when the fear memory was no longer triggered by external CS, indicating that the artificial reactivation of a specific neuronal ensemble was sufficient to evoke the extinguished fear response. Both the density and distribution of phospho-STAT3-positive cells (mainly astrocytes, microglia and endothelial cells) was similar in GF-IL6 and GF-IL6STAT1 KO mice. In the proposed method, respiratory signal is estimated by calculating an envelope curve from the detected T waves of cardiac component. Simultaneous modulation of the exteroceptive suppression periods in the trapezius and temporalis muscles by experimental muscle pain. The norepinephrine transporter (NET) gene is an attractive candidate gene for attention-deficit hyperactivity disorder (ADHD). Using BEAS-2B bronchial epithelial cells, NF-kappaB-dependent transcription and both release and mRNA expression of IL-6 and IL-8 were examined by reporter assay, ELISA and quantitative RT-PCR. At high concentrations, Penthalaris attenuates FVIIa/TF-induced chromogenic substrate (S2288) hydrolysis and FIX activation. Particle dynamics in a symmetrically driven underdamped inhomogeneous periodic potential system.

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THE USE OF AN ELASTIC BAND TO PREVENT HAEMORRHAGE FROM THE UMBILICAL CORD. Near-atomic resolution visualization of human transcription promoter opening. The EE-treated group showed increased intestinal transit and malondialdehyde levels, while the glutathione content and superoxide dismutase activity were notably decreased, together with decreased protein gene product 9.5 and neuronal nitric oxide synthase expression in the ileum and colon. The cause of the deformity included both posttraumatic and metabolic conditions. Interestingly, no resurgence is predicted when infection- and vaccine-derived immunities wane at the same rate.

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In all, 229 patients on warfarin therapy with history of stroke were followed up in our antithrombosis clinic between January 1997 and March 2003. Exposure of the cells to cytochalasins or latrunculin B increased gene expression and release of the NF-kappaB-dependent chemokines IL-8 and GRO-alpha. MYOGLOBINURIA WITH ACUTE RENAL FAILURE POSSIBLY INDUCED BY SUXAMETHONIUM. The sensitivity, specificity, and positive and negative predictive values of CT black hole sign in predicting hematoma expansion were calculated. In the fetus, we found viral sequences and antigens in the lungs, circulating mononuclear cells, and macrophages of the liver. First, employing small surface concentrations of the Cu, Bi, and Ce species deposited onto (the unperturbed) anatase, we provided evidence that all steps of the photocatalytic event, including light absorption, charge recombination, as well as surface interaction with the pollutant and chemical output as to activity and selectivity have significance in the quantitative assessment of the enhancement of the efficiency parameter. The surrounding tissues and structures were compressed against each other. Recent studies have revealed that circRNAs are stable and widely expressed, and often exhibit cell type-specific or tissue-specific expression. Patients with primary antiphospholipid syndrome (PAPS) may evolve to systemic lupus erythematosus (SLE), even many years later. Pediatric arterial ischemic stroke is relatively rare but carries a considerable impact and high risk of recurrence--especially in patients with sickle cell disease and various forms of vasculopathy.

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Serum electrophoresis detected a monoclonal peak and immunoelectrophoresis revealed an immunoglobulin M kappa component. We therefore analysed the time-course of the two of major lysosomal cathepsins (cathepsin B/D) and caspase-3 expression in brain and evaluated how DFX might affect these proteins and the parameters concerning early brain injury (EBI) after SAH. It is concluded that in select cases MR may obviate the need for more invasive procedures to establish the diagnosis of pulmonary sequestration. Bioorganic Investigation of Multicationic Antimicrobials to Combat QAC-Resistant Staphylococcus aureus. Induction of apoptosis in HepG2 cells by solanine and Bcl-2 protein. Cost-Minimization and Budget-Impact Analysis of Fixed-Dose Combination Inhalers in Treatment of Copd in Slovenia. Spin-echo fluorine magnetic resonance imaging at 2 T: in vivo spatial distribution of halothane in the rabbit head. In this study MS-CT was best suited to predict biomechanical strength of trabecular bone. Growth cones in the superior cervical sympathetic ganglion in human foetus aged 23 weeks.

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Hypergastrinemia increases gastric epithelial susceptibility to apoptosis. The relation between interatrial block and asymptomatic atrial fibrillation can provide an insight to the increased risk of ischemic stroke in patients with interatrial block. Transinfection of CD and HSV-tk double suicide genes has a powerful antitumor effect. Mechanisms of murine cranial suture patency mediated by a dominant negative transforming growth factor-beta receptor adenovirus. Attempted and committed suicides were most commonly done with zinc phosphide, and then come rat poisons. Moreover, there are many contradictory reports showing either induction, no changes or even down-regulation of VEGF in specimens taken from patients with CLI, as well as in samples collected from animals subjected to hindlimb ischemia.

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Review: Utilization of antagonistic yeasts to manage postharvest fungal diseases of fruit. Preoperative earphone, aided word recognition scores, and speech intelligibility index. Umbilical cord blood mesenchymal stem cells did not differ from cells isolated from adipose tissue and skin by the main parameters (by morphology, expression of surface markers, and differentiation potential). marginale obtained from infected cattle in the State of Minas Gerais, Brazil, where A. Quantitative analysis of morphological characters of the head was used to reconstruct the evolutionary history of the tropicopolitan bug Triatoma rubrofasciata (De Geer) (Hemiptera: Reduviidae) and seven species of Old World Triatoma. Measurement of ganciclovir concentration in human plasma by ultra-performance liquid chromatography-tandem mass spectrometry. Enzyme-catalyzed formation of beta-peptides: beta-peptidyl aminopeptidases BapA and DmpA acting as beta-peptide-synthesizing enzymes.

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RSV neutralization by palivizumab, but not by monoclonal antibodies targeting other epitopes, is augmented by Fc gamma receptors. Knockdown of prolactin receptors in a pancreatic beta cell line: effects on DNA synthesis, apoptosis, and gene expression. We sought to determine if there was a persistent effect after treatment, by testing spatial learning of embolized rats after nefiracetam therapy. These differences can be partially explained by polymorphisms of the genes encoding proteins involved in mediating and controlling the innate immune response, the inflammatory cascade, coagulation, and fibrinolysis. Stochastic relevance analysis of epileptic EEG signals for channel selection and classification. Myasthenia gravis (MG) is a rare disorder involving neuromuscular junction. A strong deficit in BW and GA followed after premature abruption of placenta, after eclampsia, placenta praevia, cervical cerclage, partus premature imminens, bleeding in the 2nd trimester, hypertension and hospitalization, namely when repeated. Correction: Immunological Priming Requires Regulatory T Cells and IL-10-Producing Macrophages To Accelerate Resolution from Severe Lung Inflammation. Association of beta-adrenoceptor polymorphisms with max oral dose of protonix cardiac autonomic modulation in Japanese males.

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Chronic obstructive pulmonary disease (COPD) is a treatable disease characterized by progressive airflow limitation. A REVIEW OF FORTY-FIVE AND RE-EVALUATION OF THE INCIDENCE AND ANTIBIOTIC SENSITIVITIES. But reasons that the difficult diagnosis of early femur head necrosis, localized effect of tantalum rod, different experience of medical worker,caused the contentions about effect of tantalum rod implanting. Comparison of stem cell behaviors between indigenous high and low-CD24 percentage flagyl antibiotic with food expressing cells of stem cells from apical papilla (SCAPs). The procedure was successful in all patients, with operative time of 45-115 min. The snow vole (Chionomys nivalis, Martins, 1842) is a common species in the Bulgarian high mountains. Differentiation of Isomeric Ginsenosides by Using Electron-Induced Dissociation Mass Spectrometry. Urinary calcium excretion in patients with calcium-containing nephrolithiasis.

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The orientation is easily observed in 31P- and 2H-nuclear magnetic resonance spectra where the intensity of the perpendicular edges of the powder lineshapes are enhanced. A neurodevelopmental approach to cognitive and behavioral assessment in epilepsy. Perceived credibility of ICBT is a strong predictor of treatment response. We reviewed our retrospective database of patients with aneurysmal SAH. The mechanism of suppression and regulation of Fcp1-2 protein activity by centromeric DNA is discussed. The purpose of this study was to examine the reproducibility of NPD measurements performed in a single center. Adhesion proteins such as integrins and cadherins also constitute receptors for inside-out and outside-in signaling within proteolipidic platforms.

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The L-NAME-resistant component of the depressor response to ACh was attenuated by ebselen, a glutathione peroxidase mimic. This result may explain the relative decrease in incidence of various solid tissue tumours observed in Down syndrome, given the role of endostatin as a potent inhibitor of tumour-induced angiogenesis in both human and animal models. In addition, whole blood cultures were exposed in vitro to low dose radiation, a contrast medium, and radiation together with the contrast medium. In neurosurgical patients, head lice infestation may be a potential risk factor for peri-operative complications. orientalis appears to express some restriction and modification, because highest transformation frequencies (10(6)/micrograms of DNA) were obtained when plasmid pIJ702 was modified by passage in A. In this study, peptide sequences of HHHHHHC and GGGGY (Y-tag) were genetically fused to the N- and C-termini of streptavidin (C-SA-Y), respectively, and C-SA-Y was mixed with horseradish peroxidase and thiol-functionalized 4-arm polyethylene glycol to yield a redox-sensitive C-SA-Y immobilized hydrogel (C-SA-Y gel). majuscula are currently being evaluated for their production of secondary metabolites. Deficiency in incisions produced by XPF at the site of a DNA interstrand cross-link in Fanconi anemia cells. Lateral osteophytes do not represent a contraindication to medial unicompartmental knee arthroplasty: a 15-year follow-up. The formal orientation processes and the critical care training program, Essentials of Progressive and Intensive Care, are detailed.

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We report that homology-directed repair of a DNA double-strand break within a single copy Green Fluorescent Protein (GFP) gene in HeLa cells alters the methylation pattern at the site of recombination. These tendon-muscle groups have developed from superior and inferior mesenchymal complexes. The use of virtual reality (VR) training tools for medical education could lead to improvements in the skills of clinicians while providing economic incentives for healthcare institutions. The aching surgeon: a survey of physical discomfort and symptoms following open, laparoscopic, and robotic surgery. Failure of the stereoisomeric mixture (containing all four stereoisomers including the pheromone) to attract males is due to inhibitory characteristics of the (2R,7R)- and (2S,7R)-stereoisomers. The amplitude of the signal is pH dependent, as expected for an energy coupling step in the enzymes reaction. LACTOSE CONTENT OF MAMMARY GLANDS OF PREGNANT RATS NEAR TERM: EFFECT OF REMOVAL OF OVARY, PLACENTA AND FOETUS. Underlying all of these changes are the even more fundamental enabling factors of genetic instability on both the chromosomal and the gene level. Studies published between 1985 and 2006 were included if they reported, in English, a controlled trial of an intervention designed to improve the management of older adults in the acute care setting.

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