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Oncoxan (Cyclophosphamide)
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Oncoxan

Oncoxan is used to treat various types of cancer. It is a chemotherapy drug that works by slowing or stopping cell growth. Oncoxan also works by decreasing your immune system's response to various diseases.

Other names for this medication:
Cyclomet, Cyclophosphamide, Cycloxan, Cycram, Cycrame, Cydoxan, Cyphos, Eldamide, Endoxan, Ledoxan, Neophos, Neosar, Oncomide, Oncophos, Oncoxan

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Also known as: Cyclophosphamide

Description

Cyclophosphamide is used to treat cancer of the ovaries, breast, blood and lymph system, and nerves (mainly in children). Cyclophosphamide is also used for retinoblastoma (a type of eye cancer mainly in children), multiple myeloma (cancer in the bone marrow), and mycosis fungoides (tumors on the skin). It belongs to the group of cancer medicines called alkylating agents.

Cyclophosphamide is also used for some kinds of kidney disease.

Cyclophosphamide interferes with the growth of cancer cells, which are then destroyed by the body. Since the growth of normal body cells may also be affected by cyclophosphamide, other effects will also occur. Some of these may be serious and must be reported to your doctor. Other effects, like hair loss, may not be serious but may cause concern. Some effects may not occur for months or years after the medicine is used.

Before you begin treatment with cyclophosphamide, you and your doctor should talk about the benefits of this medicine as well as the risks of using it.

This medicine is available only with your doctor's prescription.

Dosage

Take Oncoxan tablets by mouth. Swallow Oncoxan with water. Take your doses at regular intervals. If you want to achieve most effective results do not stop taking Oncoxan suddenly.

Overdose

If you overdose Oncoxan and you don't feel good you should visit your doctor or health care provider immediately.

Storage

Store at room temperature at or below 25 degrees C (77 degrees F) away from moisture and heat. This medicine can be stored at room temperatures of up to 30 degrees C (86 degrees F) for a short time. Protect from temperatures above 30 degrees C (86 degrees F). Throw away any unused medicine after the expiration date. Keep out of the reach of children.

Side effects

The most common side effects associated with Oncoxan are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.

Contraindications

Many medicines have not been studied specifically in older people. Therefore, it may not be known whether they work exactly the same way they do in younger adults. Although there is no specific information comparing use of cyclophosphamide in the elderly with use in other age groups, it is not expected to cause different side effects or problems in older people than it does in younger adults.

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Bioassays were performed to evaluate the impact of soil characteristics on Cd, Cu, Pb, and Zn uptake by larvae of Tenebrio molitor. Synthesis and pharmacological characterisation of a series of products obtained by coupling the H(3)-antagonist SKF 91486 through appropriate spacers with the NO-donor 3-phenylfuroxan-4-yloxy and 3-benzenesulfonylfuroxan-4-yloxy moieties, as well as with the corresponding furazan substructures, devoid of NO-donating properties, are reported. Comparison with solar, meteoritic, and terrestrial abundances reveals depletiozt of volatile elements and enrichment of the rare earths titaniunm, zirconium, yttriuntm, and hafnium. The cortactin expression levels in DU145, LNCaP and PC3 prostate cancer cells, and in PrEC normal human prostate epithelial cells were evaluated by western blot analysis. The axon initial segment as a possible determinant of retinal ganglion cell dendritic geometry. The demonstration of the connection of cause in the professional allergic pathology not tabulated. Here, we report on a very severe form of BPES resulting from a missense mutation outside the forkhead domain. Mechanistic modelling suggests that the size of preneoplastic lesions is limited by intercellular induction of apoptosis in oncogenically transformed cells.

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Immunohistochemical studies showed that immune cells formed clusters or foci in the livers of old mice, preferentially near the perivascular regions. Benzophenone-containing fatty acids and their related photosensitive fluorescent new probes: design, physico-chemical properties and preliminary functional investigations. Gramicidin A (the major component of gramicidin D) is a highly hydrophobic peptide with very little solubility in water. We present a rare case of cerebellar metastasis, one that mimics a solid type cerebellar hemangioblastoma and because of which it was very hard to reach accurate preoperative diagnosis. Ablation catheter entrapment by chordae tendineae in the mitral valve during ventricular tachycardia ablation. Although elbow injuries and fractures of the forearm are common in children, the combination of these injuries is rare. Patient age, time since amputation, the type of amputation, and the neuroma volume were not related to the presence of pain. The frequency of maxillary sinusitis of dental origin (MSDO) is under estimated.

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The 52 kDa subunit of the peripheral-plasma-membrane insulin-stimulated high-affinity cyclic AMP phosphodiesterase can be specifically detected by the antibody PM1 by Western-blotting procedures and also can be immunoprecipitated from a hepatocyte extract. Intraoperative inhaled iloprost could prevent primary graft dysfunction and preserve allograft function, thus reducing the length of ventilator care and intensive care unit stay, and improving the overall early post-transplant morbidity in patients undergoing lung transplantation. Also, in vitro, in the two aneurysms the dilation as a function of pressure was measured using the markers on the surface before and after the thrombus was removed. Finally, an experimental process is proposed to validate the accuracy of the different codes and their abilities in simulating the neutron capture by the manganese bath. Synthesis and antituberculosis activity of new hydrazide derivatives. Even so, at an ophthalmological level, they could produce irreversible visual damage, which is why it is important to have ophthalmological evaluation and proper follow up. In patients undergoing surgical ventricular restoration, transventricular edge-to-edge repair provides an effective alternative to conventional mitral valve surgery. In group 2, a single pre-operative 700 cGy radiotherapy session was added for males undergoing one-stage bilateral procedures or the second stage of a two-stage procedure when HO had formed on the first hip.

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PD98059 and UO126, p42/44 MAP kinase inhibitors, blocked strain-induced proliferation. Analyses of purified rat heart mitochondria from normal and streptozocin-treated diabetic rats show increased mitochondrial O-GlcNAc transferase (OGT) and a concomitant decrease in the mito-specific O-GlcNAcase (OGA). Was it a Case of Meningeal Hemorrhage, Hysteria, or Malingering?. Sinonasal papillomas are relatively rare, benign epithelial tumours of the nasal cavity. The exploration of seven physiologically different white rot fungi potential to produce cellulase, xylanase, laccase, and manganese peroxidase (MnP) showed that the enzyme yield and their ratio in enzyme preparations significantly depends on the fungus species, lignocellulosic growth substrate, and cultivation method. The model consists of an adsorption energy gain for the adsorbing particles and the Canham-Helfrich membrane bending energy, in which the spontaneous curvature is coupled with the adsorption area. the CL response related to a defined PMNL number, increases with the age of investigated healthy individuals.

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Operative management of deeply infiltrating endometriosis: results on pelvic pain symptoms according to a surgical classification. The infiltrating cells thus markedly resembled natural killer (NK) cells in their cytochemical characteristics and surface markers. We aimed to provide a comprehensive review of the current literature concerning this rare surgical pathology. Standardization of surgical procedures for identifying best practices and training. Natural history of Podontia congregata Baly, 1865 a flea beetle endemic to southern India, is reported for the first time. Neither thiol had any effect upon the development of the edema when administered in large, repeated doses.

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Histological examination was revealed a spindle cells and ganglion cells in much fiber which was positive for immunostaining of S-100 ptotein. BPT and preschool age group provided the best model fit and more strongly predicted outcome than broad treatment type classifications (e.g., Play Therapy or Cognitive Behavior Therapy). IBS diagnosis was determined by Rome III criteria, negative screening blood tests, and normal colonoscopy. The article argues that the public-private arrangement for water supply and sanitation infrastructure management in the Tamale Metropolis has done nothing that an invigorated public sector could not have possibly achieved. Leiomyoma of the foot: sonographic features with pathologic correlation. Sex and age differences in body-image, self-esteem, and body mass index in adolescents and adults after single-ventricle palliation. Functional foods: health claim-food product compatibility and the impact of health claim framing on consumer evaluation. Thirty cases of lentigo maligna melanoma were analyzed using indirect immunohistochemical staining. Treatment with FX inhibited both binding of PBAN to the PBAN-R and the pheromonotropic response as reflected by the production of the main pheromone component, Z-11-hexadecenal. Using systematic alanine mutagenesis of amino acids conserved between different beta integrin cytoplasmic domains, we identified the tryptophan residue at position 775 of human beta(1) integrin as specific and necessary for integrin-mediated protein kinase B/Akt survival signaling.

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Controversial cytogenetic observations in mammalian somatic cells exposed to extremely low frequency electromagnetic radiation: a review and future research recommendations. Scavenger probe sampling for determining the concentration of certain gaseous free radicals and atoms has been used to study flames and electric discharges. Growth inhibition to different degrees of MEK and AKT inhibition, either singly or in combination using 96-h sulphorhodamine assays was then studied. Numerous terminals formed synaptic contacts on dendritic shafts. Because of the importance of signaling studies to this translational work, a detailed example of the strategy and tools that can be employed to define the biochemical mechanism of MKK4-mediated metastasis suppression is presented. Probiotics are able to attenuate intestinal inflammation, being considered as safe when chronically administered. Tightened physical and electronic controls can prevent misuse of data, minimize the risk of security breaches, and help maintain the reputation and integrity of public health agencies. Cytogenetic studies on blood lymphocytes from patients with Schistosoma mansoni.

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Development of a broadband reflectivity diagnostic for laser driven shock compression experiments. Detection of melamine using commercial enzyme-linked immunosorbent assay technology. Peptide X was introduced intramuscularly, 33 pg/kg, daily during 28 days after balloon injury. Leadership training for oral health professionals: a call to action. Specific aspects in the marketing of medical services derive from their nature as a service and the determinants of perceived service quality. laevis Nkx5.3 and SOHo by phylogenetic comparison to chicken, medaka, and zebrafish orthologs. Data, obtained by employing long-term diffusive samplers over a three-month period, are compared with a parallel experiment showing the day-night indoor/outdoor trend. Five different orientations relative to the baffle support of the modified cannula were evaluated at each position to assess the turbulent flow. Traditionally, endoscopic transsphenoidal pituitary surgery is performed using 2-dimensional (2D) endoscopes, which lack depth of field and contribute to image distortion.

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Structure and properties of small molecule-polymer blend semiconductors for organic thin film transistors. Its highly alkalic, sodium-rich lava, although different in composition from the more common calcium-rich carbonatites, provides the opportunity for observations of the physical characteristics of carbonatite melts. The addition of isthmuses did not significantly alter the ratio of instrumented to unprepared areas at total root canal level. The electron mobilities for compounds 1, 4, and 5 are 3.45 x 10(-2), 2.90 x 10(-2), and 1.40 x 10(-2) cm(2)/(V s), respectively. Determination of 226Ra at ultratrace level in mineral water samples by sector field inductively coupled plasma mass spectrometry.

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The benefits of haptic feedback in laparoscopic surgery training simulators is a topic of debate in the literature. Hypertrophic scar is one of the unique fibrotic diseases in human. New technologies for sequencing, aided by friction-free approaches to data sharing, could have an impact on public health efforts. A biomechanical analysis of gap formation and failure mechanics of a xenograft-reinforced rotator cuff repair in a cadaveric model. The anuran ear is frequently used for studying fundamental properties of vertebrate auditory systems. Sinonasal acinic cell carcinoma is a distinct plavix medication generic low-grade carcinoma that can be distinguished from other neoplasms by light microscopy and histochemical staining methods. In a cohort study, information on an individual is taken at baseline, after which it usually remains fixed. Data from two almost simultaneous balloon soundings show that ozone and dust in combination are transported from their stratospheric reservoirs into the troposphere by way of thin laminae measuring about 1 kilometer vertically by at least 480 kilometers horizontally.

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So far, the inferences for frameshifts and selective pressures on the C-terminal domain are made for old duplications for which the exact selective pressures are obscured by evolutionary time. Evidence suggested that climatic and anthropogenic driven ecological changes coupled with the location of piggeries in orchard and the design of pigsties allowed the spill-over of this novel paramyxovirus from its reservoir host into the domestic pigs and ultimately to humans and other animals. Concurrent validity of the Microsoft Kinect for Windows v2 for measuring spatiotemporal gait parameters. Other mechanisms, such as upregulation of enzymes involved in oxidative phosphorylation, cellular respiration, V-ATPases, aerobic respiration or spermine synthetase, as well as reduced growth rate, may also be involved. Correlation between bladder volume and irradiated dose of small bowel in CT-based planning of intracavitary brachytherapy for cervical cancer. Implicated most often in tracheobronchitis, it is the second most frequent agent responsible for community-wide bacterial pneumonia, and in addition it probably causes asthma exacerbations. The reading distances that the postal workers had while sorting the mail was inverted to the distances in their regular progressive lenses. adenophora inhibited the spore germination and gametophyte development of M. We demonstrate the existence of an orbital Coulomb phase as the exact ground state of a p-orbital exchange Hamiltonian on the diamond lattice. The refeeding syndrome is common among patients with anorexia nervosa.

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The management and control should be improved in production and usage of highly toxic pesticides including organophosphorus insecticides, rodenticides, and herbicides. Several spasmogenic mediators released after SAH may cause vasospasm through Rho-kinase-mediated increase in calcium sensitization. T cell receptor beta genes of human CD4 and CD8 single positive cells developing in HU and SW thymus grafts showed similar, normal CDR3 length distributions. These modifications, observed particularly in brain and liver compared with other organs, were enhanced by long-term alcohol exposure and, interestingly, were significantly reduced with acetyl carnitine supplements. Instead, they extend in a subcutaneous tissue plane to the margins of the neck or facial defect and transfer the entire intervening skin bridge with the deltopectoral flap. In addition, the biocompatibility and effectiveness of two selected gel candidates were evaluated in vivo by evaluating the benefit of a single intraarticular injection of these new treatments in a model of osteoarthritis in rabbits.

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Structure of human chromosomes studied by atomic force microscopy. Nutritional and genetic determinants of vitamin B and homocysteine metabolisms in neural tube defects: a multicenter case-control study. Two major domains were identified: the conserved domain containing conserved sequence blocks and cis-regulatory structures that may be related to the transcription and the origin of replication of mitochondrial DNA, and the variable domain, containing high sequence and length variation. The TAR of multilamellar vesicles from dipalmitoylphosphatidylcholine (DPPC) and dimyristoylphosphatidylcholine (DMPC) was measured in the megahertz range and the variations in the radiation intensity during the lipid phase transition were recorded. Functional study of immature dendritic cells co-transfected with IL-10 and TGF-beta 1 genes in vitro. Composition of minced meat part B: A survey of commercial ground meat. These data may help to explain the controversy in previous studies and to promote studies focused on the trigger mechanisms of stroke. Protease inhibitors are useful tools for increasing the inhibitor potential of plasma. The study was done on freshly dissociated neurons in order to minimize the influence of the culture conditions on the expression of the current or of substance P.

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Effect of fatigue on torque output and electromyographic measures of trunk muscles during isometric axial rotation. Origins and movement of fluids during deformation and metamorphism in the canadian cordillera. Oxygen uptake kinetics during moderate and heavy intensity exercise in humans: the influence of hypoxia and training status. In contrast, we found that levels of proviral DNA and 2-LTR circles were significantly lower under treatment only when groups of specimens that were homogeneous, with respect both to plasma viraemia and infectious cell frequency, were compared. The data imply that auto-SCT can overcome the adverse prognostic impact tetracycline list antibiotics of the non-GC phenotype in patients with high-risk DLBCL and warrant additional prospective studies. Sympathetic activation and endothelial dysfunction in polycystic ovary syndrome are not explained by either obesity or insulin resistance.

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The response of the T-cell lines to the antigen was major histocompatibility complex (MHC)-restricted. Increasing task difficulty also led to significant increases in performance variability. This resembled the disappearance of chloride conductance in normal medium, suggesting that synthesis of this channel ceases following denervation. Such an approach must include efficacy, safety, convenience, and cost effectiveness. Antazoline is an cleocin t gel generic antihistaminic agent with antiarrhythmic properties.

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Recent work has shown that claudins form barriers, determined by the paracellular electrical resistance and charge selectivity, and pores in the TJ strands. Ostrich meat: Physico-chemical characteristics and comparison with turkey and bovine meat. On the non-stimulated hemisphere, RMTs were increased and MEPs were decreased only in the healthy control group. Comparison of two stream temperature models and evaluation of potential management alternatives for the Speed River, Southern Ontario. the incomplete filtered moving object image, can be better resolved by parallel integration of multi-channel visual information, however, the second part, i.e. We also microstimulated the cortical motion area MT and tested for antidromic activation of pulvinar to identify neurons projecting to MT (and to determine the presence of orthodromic input back to pulvinar). These findings would suggest that polymorphism of cytokine genes may not play as crucial a role in healthy ageing as previously believed.

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The classical cytosolic Trx1 and truncated Trx80 are released from cells. Their tolerability is in general better in comparison to the classic neuroleptics, but sometimes it happens that unfavorable drug-induced side-effects during treatment (e.g. There were no regional differences of total P450 content, as well as major CYP450 isozymes (CYP 1A, 2A, 2B, 2C, 2D, 2E1 and 3A4) in cynomolgus monkeys by westernblot analysis. Isolation and characterization of the gene encoding the alpha-subunit of the rat pituitary glycoprotein hormones. Besides, cytogenetical endpoints (chromosome aberrations, micronuclei, mitotic index and sperm head anomaly) were also analyzed. A non-ionic surfactant, Brij 35, was found to be a good solving agent, extracting ATZ without causing any retardation effect on the photolysis protonix dose process. Right upper lobectomy with mediastinal lymph node dissection, and partial resection of the right lower lobe were performed. Thirty minutes of footshock resulted in significant increases of the ratios of the dopamine (DA) catabolite, dihydroxyphenylacetic acid (DOPAC), to DA in prefrontal cortex, nucleus accumbens, striatum, hypothalamus, and brainstem, and of homovanillic (HVA)/DA ratios in nucleus accumbens, striatum, amygdala, and hypothalamus.

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Anti-D monoclonal antibodies were used to characterize the presentation of RhD epitopes on the RBCs. In pregnancies with vascular complications, circulating MP with procoagulant potential may be part of the exacerbation of these responses. Pneumocystis carinii were pretreated with Zymolyase for increased susceptibility to chaotropic agents. These investigations, beyond the biophysically relevant results addressing the long-standing question of the actual role of the enzyme structure on the enzyme activity, are also of some methodological interest since they offer a further computational perspective for including the electronic degrees of freedom into the modeling of rather complex molecular systems. Medical treatment for neurocysticercosis: drugs, indications and perspectives. Among these compounds, 3-methylbutanal, methional, and dimethyltrisulfide (DMTS) were present in aged sake at concentrations exceeding their odor thresholds, and the highest odor active value was observed for DMTS. As key mediators of T cell dependent immunity, DCs are considered primary targets for initiating immune responses in infectious diseases and cancer. After behavioral assessment, tissues from the dorsal quadrant of the spinal cord (SC) and dorsal root ganglion (DRG) underwent full-genome microarray analyses.

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Treatment of HRMECs with conditioned media from AKAP12-overexpressing astrocytes reduced phosphorylation of protein kinase Czeta (PKCzeta), decreased the levels of vascular endothelial growth factor (VEGF) mRNA and protein, and increased thrombospondin-1 (TSP-1) levels, which led to antiangiogenesis and barriergenesis. Susceptibility was tested in duplicate by eight biomedical scientists in one laboratory and by routine procedures in seven different laboratories. Separation of positional isomers by the use of coupled shape-selective stationary phase columns. A total of 469 Singapore Chinese children aged 48 to 72 months were recruited through the Strabismus, Amblyopia and Refractive Error Study in Singaporean Chinese Preschoolers (STARS) from 2006 to 2008. In this review, we will provide an updated overview of Che-1/AATF activities, from transcriptional regulation to DDR. Dietary GL, GI, or intake of carbohydrates and mono- and disaccharides were not associated with pancreatic cancer risk in this cohort.

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The purpose of this investigation was to compare the resistance to crack propagation of 9 flowable composites as measured by the fracture toughness. Effective use of modeling and simulation in designing bioequivalence and comparability studies of large-molecule compounds: the case of erythropoietin. Some LCs showed cytostatic effects, suppressing cell growth via S-phase arrest and without apoptosis in U937 cells. Optimization of electrocoagulation process for the simultaneous removal of mercury, lead, and nickel from contaminated water. The evolution of the major anions and cations in the plasma and the protein loss were studied at different volumetric concentration factors. During body elongation that follows gastrulation, expression of Ttu-p68 is further restricted to the stomodaeum (derived from the micromere crescent), ventral ganglia, lateral dots (corresponding to dorsal and ventral setal sacs), ventral large cells (that resemble presumptive primordial germ cells) in segments VIII-XII, and a bilateral pair of cell clusters at the caudal end. Even though deciphering the role of these aggregates has been the object of intense research activity, their role in protein misfolding diseases is unclear. Each mAb bound only to its specific domain with affinity comparable to the binding to holotoxin. Biochemical markers of bone remodeling have been extensively used (independent of bone mass measurements) to document the efficacy of various anticatabolic and anabolic bone-modifying medications in reducing fracture risk. Can mobile phones transform healthcare in low and middle income countries?.

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