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Otrozol (Metronidazole)
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Otrozol

Otrozol eliminates bacteria and other microorganisms that cause infections of the reproductive system, gastrointestinal tract, skin, vagina, and other areas of the body. Antibiotics will not work for colds, flu, or other viral infections. This medication is sometimes prescribed for other uses; ask your doctor or pharmacist for more information.

Other names for this medication:
Aldezol, Anamet, Anazol, Aristogyl, Bemetrazole, Buccoval, Dumozol, Emedal, Entizol, Metrocream, Metrogel, Metrol, Metrolotion, Metrolyl, Metronidazole, Metronide, Metropast, Metrosil, Metrovax, Metrozole, Micogyl, Nidazea, Otrozol, Patryl, Protozol, Riazole, Rozex, Taremis, Tricodazol, Vagizol

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Imdur, Retin, Prometrium, Fosamax, Prandin, Emcor, Spasomonyl, Vezocal, Telekast, Fenofibrate, Metatop, Domidis,

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Also known as: Metronidazole

Description

Metronidazole is used to treat bacterial infections in different areas of the body. The extended-release tablets are used to treat women with vaginal infections (bacterial vaginosis).

Metronidazole belongs to the class of medicines known as antibiotics. It works by killing bacteria or preventing their growth. However, this medicine will not work for colds, flu, or other virus infections.

This medicine is available only with your doctor's prescription.

Dosage

This section provides information on the proper use of a number of products that contain metronidazole. It may not be specific to Otrozol. Please read with care.

Use this medicine exactly as directed by your doctor. Do not use more of it, do not use it more often, and do not use it for a longer time than your doctor ordered.

This medicine is to be used only in the vagina. Use it at bedtime, unless your doctor tells you otherwise.

Do not get it into your eyes, nose, mouth, or skin. If this medicine does get into your eyes, wash them out right away with large amounts of cool tap water. If your eyes still burn or are painful, check with your doctor.

This medicine comes with a patient information leaflet and patient instructions. Read and follow the instructions carefully. Ask your doctor if you have any questions.

Wash your hands with soap and water before and after using this medicine.

Nuvessa™ is available inside a prefilled applicator. The applicator is open at one end where you will insert the plunger and has a pink cap on the other end where the medicine will come out.

Vandazole® is in a tube. You will use an applicator to put the gel into your vagina. The applicator has a plastic tube called a barrel that is open at one end and has a plunger (another piece of plastic that can move inside the barrel) at the other end.

To use the medicine:

To fill the applicator: For cream or gel dosage forms: Nuvessa™: With the pink cap still on, push the tip of the plunger into the open end of the prefilled applicator. Pull the cap off before you insert the applicator into your vagina. Vandazole®: Break the metal seal at the opening of the tube by using the point on the top of the cap. Screw the applicator onto the tube. Squeeze the medicine into the applicator slowly until it is full. Remove the applicator from the tube. Replace the cap on the tube. For vaginal tablet dosage form: Place the vaginal tablet into the applicator. Wet the vaginal tablet with water for a few seconds. To insert vaginal metronidazole using the applicator: For all dosage forms: Relax while lying on your back with your knees bent (or in any position that you feel comfortable). Hold the full applicator in one hand. Insert it slowly into the vagina. Stop before it becomes uncomfortable. Slowly press the plunger until it stops. Withdraw the applicator. The medicine will be left behind in the vagina. Remove the applicator from your vagina. Use each applicator only once, and then throw it away.

To help clear up your infection completely, it is very important that you keep using this medicine for the full time of treatment, even if your symptoms begin to clear up after a few days. If you stop using this medicine too soon, your symptoms may return. Do not miss any doses. Also, continue using this medicine even if your menstrual period starts during the time of treatment.

The dose of this medicine will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of this medicine. If your dose is different, do not change it unless your doctor tells you to do so.

The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.

For bacterial vaginal infections: For vaginal dosage form (cream): Adults—One applicatorful (500 milligrams [mg]), inserted into the vagina. Use the medicine 1 or 2 times a day for 10 or 20 days. Children—Use and dose must be determined by your doctor. For vaginal dosage form (gel): Nuvessa™: Adults and children 12 years of age and older—One applicatorful (5 grams [g]) inserted into the vagina once (at bedtime). Each applicatorful of Nuvessa™ contains 65 mg of metronidazole. Children younger than 12 years of age—Use and dose must be determined by your doctor. Vandazole®: Adults—One applicatorful (5 grams [g]) inserted into the vagina once a day (at bedtime) for 5 days. Each applicatorful of Vandazole® contains 37.5 mg of metronidazole. Children—Use and dose must be determined by your doctor. For vaginal dosage form (tablets): Adults—One 500 milligram (mg) tablet, inserted high into the vagina. Use the medicine once a day in the evening for 10 or 20 days. Children—Use and dose must be determined by your doctor.

Overdose

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

Overdose symptoms may include nausea, vomiting, and loss of balance or coordination.

Storage

Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing.

Keep out of the reach of children.

Do not keep outdated medicine or medicine no longer needed.

Ask your healthcare professional how you should dispose of any medicine you do not use.

Detailed Metronidazole topical dosage information

Side effects

The most common side effects associated with Otrozol are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.

Contraindications

Tell your doctor if you have ever had any unusual or allergic reaction to this medicine or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.

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The aim of this study was to investigate placental transfer of clarithromycin in a well-studied placental perfusion model to determine whether clarithromycin surpasses the transfer rate of other macrolide antibiotics in similar models. Aside non-classical membrane receptors with a high affinity for aldosterone, these effects involve phospholipase C, phosphoinositide turnover, intracellular pH and calcium, protein kinase C and tyrosine kinases. A practical synthesis for the core structure of a family of selective prostaglandin D2 receptor antagonists. Characterization of a novel five-transmembrane domain cholecystokinin-2 receptor splice variant identified in human tumors. Orally administered DTPA di-ethyl ester for decorporation of (241)Am in dogs: Assessment of safety and efficacy in an inhalation-contamination model. Relationship between detrusor pressure and urinary flow rate in males with an intraurethral prostatic spiral. Because of recent advances in flow cytometry and in the development of fluorescent labeling compounds, such as allophycocyanin, autofluorescence can be minimized by the use of red excitation and emission wavelengths. Gradients of transcription factor expression in the cortical primordium regulate molecular regionalization and potentially the patterning of thalamic projections. Using a monoclonal antibody affinity column, the keratinocyte transglutaminase has been purified approximately 1000-fold from non-ionic detergent extracts of the particulate fraction of a squamous cell carcinoma line. Reduced amygdala-orbitofrontal connectivity during moral judgments in youths with disruptive behavior disorders and psychopathic traits.

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As with polyethylenes obtained by conventional polymerization, the fold length in the normal alkanes varies with crystallization temperature, but it is always an integral reciprocal of the full chain length. Notably, Smad4 also promoted short Bim isoform and Bax expression and release of cytochrome c only in ERalpha-positive MCF-7 tumor xenografts. The NW arrays showed a more than 200 times faster charge transport and a factor four lower defect state density than conventional rutile nanoparticle films. The microneurograms revealed neuronal tissue constituents at subfascicular level. Presently, there are several classifications according to the venous restrictive condition. To achieve targeted gene expression, we developed a novel heat-inducible gene expression system in which thermal energy generated by Mn-Zn ferrite magnetic nanoparticles (MZF-NPs) under an alternating magnetic field (AMF) was used to activate gene expression. It is difficult to understand how these behaviors differentiate given that normal untreated males sing and copulate in a male-typical manner, whereas females never show these behaviors. Tetrazolium-based plaque assay for HIV-1 and HIV-2, and its use in the evaluation of antiviral compounds. The improvement of topographical disorientation was attained in 3 months, while the inability of the sense of quarters and manipulating visuo-spatial information remained unchanged. Immediate complete angiographic obliteration was achieved in three patients.

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We further identify polo-like kinase 1 (PLK1) as a substrate of PTEN phosphatase. Future clinical applications are expected to involve the development of new therapeutic strategies for transplantation and various inflammatory cardiovascular, gastrointestinal and neurological diseases. However, data from the studies on different populations showed that IR may predispose to such conditions as miscarriage, preeclampsia and macrosomia. Only the combined use of a GnRH antagonist protocol with GnRHa triggering and subsequent single blastocyst transfer or embryo/oocyte freezing will completely abolish the risk of OHSS after ovarian hyperstimulation. Our findings may be useful for investigating the genetic factors concerning the susceptibility to MDD in Japanese population. It improves sampling of the anterior and apical prostate, and should be included as part of the diagnostic algorithm to reduce extensive repeat biopsy. Ionic liquids were formed via metathesis reactions of the hydrochloride salt of the PWSDs with a range of lipophilic counterions.

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Shoulder pain and intra-articular interleukin-8 levels in patients with rotator cuff tears. There was severe stenosis of the right vertebral artery (VA) at C5-6, and head rotation to the right resulted in complete occlusion of the right VA. In comparison to isoprenaline 5-HT, prenalterol, dobutamine, salbutamol, and NE acted as partial agonists, whereas 5-CT and 8-OH-DPAT did not produce a response. Volociximab was found to significantly inhibit the growth of tumors growing subcutaneously or intramuscularly, despite a 20-fold lower affinity for rabbit integrin, relative to human. The objectives of this study are to evaluate the contributions of the popliteofibular ligament (PFL), the popliteus tendon (PT), and the lateral (fibular) collateral ligament (LCL) to the posterolateral stability of the knee by changing the sequence of selective transection. Similarly, how in viscid digesta, shear strength, plasticity and elasticity of contained particulate material may influence the permeation of the fluid phase and secretions into and out of the digesta bolus.

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In contrast to genomic imprinting, which generates maladaptation along an axis of mother-infant attachment, sexual antagonism is predicted from theory to generate maladaptation along an axis of sexual dimorphism, modulated by steroid and peptide hormones. The effects of micronutrient interventions on other domains were inconsistent. The present study was designed to investigate whether statins could prevent and invert the development of renal injury in cholesterol-fed rabbits and to find the possible mechanism of their effects by detecting gene and protein expression of lectin-like oxidized low-density lipoprotein receptor-1 (LOX-1) in the renal artery. To explore whether edaravone protects cells damage via mitogen-activated protein kinases (MAPKs) signal pathway, and which procedure of p38 be affected so as to add theories for AD pathogenesis and treatments. We show here that the two peptides are recognized by the immune system as being almost identical. The basis of regulation of medicines is an assessment of risk and benefit. To this end, we give an overview and critically discuss currently known classes of macrocyclic proteasome inhibitors. In contrast, the N-terminal domains of the Arabidopsis RPP1-WsA and flax L6 and M resistance proteins, which carry predicted signal anchors, were targeted to the endomembrane system, RPP1-WsA to the endoplasmic reticulum and the Golgi apparatus, L6 to the Golgi apparatus, and M to the tonoplast.

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Susceptibility to 16 antimicrobial agents was determined by the disc diffusion method. The diagnosis of periappendiceal abscess was confirmed later after the operation. Potential arms race in the coevolution of primates and angiosperms: brazzein sweet proteins and gorilla taste receptors. Colon perforation during percutaneous renal surgery: a 10-year experience in a single endourology centre. Arg194Trp, Arg280His, and Arg399Gln are three polymorphisms of XRCC1 that commonly exist in human. Web of Science was searched for foot and ankle articles in 4 highly cited journals from 2009 to 2013. More recently, we found heterozygous COL6A1 glycine substitutions in patients with UCMD with SSCD. With the growing availability of clinical narratives in an electronic format, automated surveillance using natural language processing (NLP) techniques may represent a better method.

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ERT seems to be a very promising new therapeutic regimen for patients with MPS I, especially for those with the less severe variants. In conclusion, our results indicate a major role of FcgammaII-R and its downstream signaling cascade in the phagocytosis of quartz particles in AM as well as in the associated generation and release of inflammatory mediators. Most conventional cancer therapies are ineffective in managing tumor metastasis. The virtual dissection reading technique allows short learning curves, which may be improved by the concurrent use of CAD, without significant effect on average reading time. Thus, a single protease may be both necessary and sufficient for Ag processing to present the majority of epitopes, at least for myoglobin. The patients were analyzed according to age, sex, tumor size, growth and tumor structure, and clinical symptoms.

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To quantify and characterize the use of the Internet to search for information about medicines. We searched for missed, unreported and ongoing trials in trial registries and in reference lists of excluded articles. Although an electron transfer mechanism has previously been established starting with DCA, our results are indicative of two competitive mechanisms using BzO as the photosensitizer, instead of singlet oxygen addition and electron transfer. Then, a simplified 1D water quality model was formulated and applied for the existing conditions and two hypothetical scenarios: (1) all coastal cities have STPs with secondary treatment and (2) all coastal cities have STPs with tertiary treatment to determine BOD(5), TN and TP concentrations in the 18 surface coastal currents. Plants and their by-products offer a diverse mixture of chemical constituents like natural antioxidants. Expansion of myeloid-derived suppressor cells with arginase activity lasts longer in aged than in young mice after CpG-ODN plus IFA treatment. These methods can also be readily adapted to examine the requirement for nerves in mouse models of skin pathology. In opposition to the orthodox method of Western blotting employing electrophoretic analysis and homogenization, the immunohistochemical investigations of XIAP provided spatial information. Here, oligoclonal immunoglobulin M (IgM) production and autoreactive antibodies are described, with a focus on antibodies directed against sperm-associated antigen 16 (SPAG16).

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Nanoparticulate system for efficient gene transfer into refractory cell targets. These findings could facilitate the identification of interventional strategies to reduce the risk of decline at different stages of susceptibility. In addition, a sharp rise has been observed in the resistance rate of gonococci to fluoroquinolones. In this study, subprophylactic anti-Xa trough levels were common in trauma patients. Realistic assumptions about extinction debt and dispersal capacity substantially increased extinction risks. Predictive value of self-rated health in pregnancy for childbirth complications, adverse birth outcomes, and maternal health. Pituitary tumor transforming gene (PTTG) is a protooncogene implicated in the pathogenesis of multiple tumor types, which stimulates fibroblast growth factor-2 secretion via PTTG binding factor (PBF). Mutation of the endoglin gene is associated with hereditary hemorrhagic telangiectasias, or Osler-Weber-Rendu syndrome, and has been studied extensively in the context of this disease. Reliable segmentation of cell nuclei from three dimensional (3D) microscopic images is an important task in many biological studies. Covalent layer-by-layer assembly of hyperbranched polyether and polyethyleneimine: multilayer films providing possibilities for surface functionalization and local drug delivery.

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Recent advances in molecular genetics of melanoma progression: implications for diagnosis and treatment. Simultaneous determination of gatifloxacin and ambroxol hydrochloride from tablet dosage form using reversed-phase high performance liquid chromatography. GFAP and vimentin were present in approximately equal amounts in differentiating astrocytes in 23-week spinal cord. In this study, the secretion of IL-18 following intracellular infection with virulent Brucella abortus 2308 in CD-1 cultured peritoneal macrophages and splenocyte cultures was investigated. T cell-derived suppressor-inducer and suppressor-effector factor reactivities are regulated by a TCR beta chain analog. Case report: vancomycin-induced thrombocytopenia in a burn patient. All men with NOA undergoing their first TESE procedure as part of a fertility treatment were included. The user testing toolset: a decision support system to aid the evaluation of assistive technology products. Hemorrhage-induced vascular hyporeactivity to norepinephrine in select vasculatures of rats and the roles of nitric oxide and endothelin. Module content included factors related to obesity, implications of weight loss efforts, classroom activities, and bias-free intervention techniques.

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Therefore, these results suggest that serum DNase levels reveal the necrotizing changes in pancreatic parenchyma. Taurolidine lock: the key to prevention of recurrent catheter-related bloodstream infections. For 82-kDa choline acetyltransferase, the presence of the unique amino-terminal nuclear localization signal plus the newly identified nuclear localization signal may be involved in a process leading to predominantly nuclear accumulation of this enzyme, or alternatively, the two nuclear localization signals may be sufficient to overcome the force(s) driving nuclear export. The enhancing effect of ET-1 on IL-25 was inhibited by an endothelin A receptor antagonist, ERK1/2 inhibitor, or p38 inhibitor, but not by an endothelin B receptor antagonist or JNK inhibitor. Differential regulation of gonadotropin hormone production in the pituitary is critical for fertility. What is known and unknown about chemotherapy-related cognitive impairment in patients with haematological malignancies and areas of needed research.

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The molecular cloning of the PTHrP gene, and the subsequent recognition of its widespread expression in normal tissues under normal physiologic conditions, has prompted intense inquiry into its biologic function. The insulin resistance syndrome (IRS) is a common disorder, which has important clinical implications. Potential link between follistatin-like protein and cardiovascular diseases. Proteome analysis of low-abundance proteins using multidimensional chromatography lasix infusion dose in acute renal failure and isotope-coded affinity tags. The simple model does not fit the average spectrum of the linearly polarized emission, although the average spectrum had the same form on two nights. The transcriptome of whole zebrafish brain showed little response to 21 days of starvation. Of these, ultrasound with color-coded duplex sonography is the preferred method in the diagnosis of vein diseases, especially in patients with suspected deep venous thrombosis (DVT) and varicosis. Maximizing the activation wave area in the LV had the most consistent correlation with CRT response, independent of pacing protocol, scar size, or lead location. Experiments gave information for general susceptibility of naked pupae of C.

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To assess the quality of life of female patients with urinary stress incontinence (USI) who were attended at the urology department cozaar generic dosage of the University Hospital at Albacete. Using the patch-clamp technique, we have identified two types of chloride channel on duct cells cultured from human fetal pancreas. Specifically, it will concentrate on reviewing the phenotypic (activity based) rather than genotypic (mechanism based) approach to develop herbal medicine useful for personalized cancer chemotherapy. This study suggests that honokiol is a potent neuroprotective agent in focal cerebral ischemia. Haploidentical hematopoietic stem-cell transplantation is an alternative transplant strategy for patients without an HLA-matched donor.

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An automatic system of clinical-diagnostic information has been applied to workers exposed to ionising radiation at the University of Naples Federico II with reference to the last 5 years. BKCa and KV channels limit conducted vasomotor responses in rat mesenteric terminal arterioles. Simvastatin (SIM), a HMG-CoA reductase inhibitor, has therapeutic effects that are not limited to cholesterol reduction. In situ analysis of smoothelin-like 1 and calmodulin interactions in smooth muscle cells by proximity ligation. Chronic liver injury by various toxic agents causes an increase in collagen biosynthetic activity, resulting in deposition of excessive amounts of collagen and rearrangement of the lobular architecture leading to hepatocellular dysfunction and portal hypertension. Based on a 3D-QSAR pharmacophore derived from a diverse set of known cyclin-dependent kinase 9 (CDK9) inhibitors and a composite pharmacophore extracted from the complex structure of flavopiridol (FVP)-CDK9, thirty novel 5-fluoro-N2,N4-diphenylpyrimidine-2,4-diamine derivatives were designed and synthesized. Behavioral health-related emergency department (ED) visits have been linked with ED overcrowding, an increased demand on limited resources, and a longer length of stay (LOS) due in part to patients being admitted to the hospital but waiting for an inpatient bed. Overexpression of Snail accelerates adriamycin induction of multidrug resistance in breast cancer cells.

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Biological and chemical irritants can be the cause of irritation in a variety of organ sites. rhBMP-7-coated implants exhibited robust radiographic bone formation. Java clone predominant in poultry production in several European countries. Mechanisms involved in the loss of excitatory post-stimulus responses by inflammation. This opens the door for assays designed to test the in vitro effects of putative cofactors on human exosome activity and will enable structural studies of preparations from endogenous sources. Combined effect of obstructive sleep apnea and chronic smoking on cognitive impairment. Perception of nursing faculty on the care: Heidegger constructions. Immunohistochemistry utilizing Keratin 903 xanax and alcohol mayo clinic , a basal cell-specific antikeratin antibody, was useful in identifying basal cells in sclerosing adenosis, thus verifying its benign nature. We utilized reverse-transcription polymerase chain reaction and BbvI digestion to demonstrate that NPCs contain Q/R-unedited GluR2, and differentiated cells contain Q/R-edited GluR2 subunits.

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