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Pionorm (Glibenclamide)

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Pionorm is an effective and affordable medication for lowering blood sugar, but it can sometimes make your blood sugar too low especially if you have kidney problems. Pionorm tells your pancreas to increase the amount of insulin it produces in your body. Insulin works to lower your blood sugar.

Other names for this medication:
Afdiex, Aviglen, Benformin, Bionil, Codica, Combidos, Daocon, Daonil, Diabetnil, Diabetrol, Diabnil, Duotrol, Dutrol, Euglucon, Glibact, Glibenclamide, Glibet, Glibson, Glifil, Glime, Glimsug, Glinil, Glitrac, Glucomin, Glucosafe, Glucosil, Glucotrac, Glunil, Glutowin, Glybenclamide, Glybovin, Glycurub, Glymep, Iscept, Melitus, Metclam, Metica, Monomet, Pionorm, Sugnil, Sugnl, Sugronil, Sycored, Symet, Triglucored

Similar Products:
Mircette, Persantine, Zetia, Eulexin, Vasotec, Triazol, Infen, Amiodarona, Enselin, Clindacyn, Triatec,

Also known as: Glibenclamide


Pionorm is used to treat high blood sugar levels caused by a type of diabetes mellitus (sugar diabetes) called type 2 diabetes. In type 2 diabetes, your body does not work properly to store excess sugar and the sugar remains in your bloodstream. Chronic high blood sugar can lead to serious health problems in the future.

Proper diet is the first step in managing type 2 diabetes, but often medicines are needed to help your body. Pionorm belongs to a class of medicines called sulfonylureas. It causes your pancreas to release more insulin into the blood stream. This medicine may be used alone or with another oral medicine such as metformin.

This medicine is available only with your doctor's prescription.

This product is available in the following dosage forms:

  • Tablet


Usual Adult Dose for Diabetes Type 2:

Doses provided as Pionorm-metformin -As Initial Therapy in Patients with Inadequate Glycemic Control on Diet and Exercise Alone: Starting dose: 1.25 mg-250 mg orally once a day -Consider a starting dose of 1.25 mg-250 mg orally twice a day for patients with fasting blood glucose (FBG) greater than 200 mg/dL or HbA1c greater than 9% Maintenance Dose: Increase in increments of 1.25 mg-250 mg per day every 2 weeks up to the minimum effective dose to achieve glycemic control Maximum Initial Dose: 10 mg-2000 mg per day -Patients with Inadequate Glycemic Control on a Pionorm (or another Sulfonylurea) and/or Metformin: Initial dose: 2.5 mg-500 mg or 5 mg-500 mg orally twice a day Maintenance Dose: Increase in increments of no more than 5 mg-500 mg to the minimum effective dose to achieve adequate blood glucose control Maximum Dose: 20 mg-2000 mg per day Comments: -Give with meals; 5 mg-500 mg dose should not be used as initial therapy due to an increased risk of hypoglycemia; initial doses should be conservative to avoid hypoglycemia largely due to Pionorm and gastrointestinal side effects largely due to metformin. -For patients who are switching to combination therapy, initial doses should not exceed the daily dose of Pionorm (or equivalent sulfonylurea) and metformin already being taken; the decision to switch to the nearest equivalent dose should be based on clinical judgement. -Addition of thiazolidinedione may be appropriate for patients not adequately controlled on Pionorm-metformin; in patients experiencing hypoglycemia, consider reducing the dose of the Pionorm component. -Monitor patients closely for signs and symptoms of hypoglycemia. Use: As an adjunct to diet and exercise to improve glycemic control in patients with type 2 diabetes mellitus.

Detailed Pionorm/metformin dosage information


Seek emergency medical attention or call the Poison Help line at 1-800-222-1222. A Pionorm overdose can cause life-threatening hypoglycemia.

Symptoms of severe hypoglycemia include extreme weakness, nausea, tremors, sweating, confusion, trouble speaking, fast heartbeats, or seizure.


Keep this medication in the container it came in, tightly closed, and out of reach of children. Store it at room temperature and away from excess heat and moisture (not in the bathroom).

It is important to keep all medication out of sight and reach of children as many containers (such as weekly pill minders and those for eye drops, creams, patches, and inhalers) are not child-resistant and young children can open them easily. To protect young children from poisoning, always lock safety caps and immediately place the medication in a safe location – one that is up and away and out of their sight and reach.

Unneeded medications should be disposed of in special ways to ensure that pets, children, and other people cannot consume them. However, you should not flush this medication down the toilet. Instead, the best way to dispose of your medication is through a medicine take-back program. Talk to your pharmacist or contact your local garbage/recycling department to learn about take-back programs in your community. See the FDA's Safe Disposal of Medicines website ( for more information if you do not have access to a take-back program.

Side effects

The most common side effects associated with Pionorm are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.


Avoid drinking alcohol. It lowers blood sugar and may increase your risk of lactic acidosis.

If you also take colesevelam, avoid taking it within 4 hours after you take Pionorm and metformin.

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