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Plaxid (Alprazolam)

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Plaxid is commonly used to treat anxiety and panic disorders. It falls into a category of medications called benzodiazepines. They are known to affect the central nervous system components and produce a calming effect, thus decreasing brain activity.

Other names for this medication:
Aderta, Aldep, Alprac, Alpram, Alprasan, Alprazan, Alprose, Alprosym, Alzam, Alzep, Alzorix, Alzotime, Anxyl, Avizolem, Coolam, Depser, Diprex, Emlol, Ezoprax, Finezol, Fluti, Fluwel, Mcalm, Mediprex, Norex, Nucalm, Optizole, Ozolam, Parazolam, Pifzot, Pronext, Pronil, Selamb, Sinaday, Somnirest, Tenil, Xerodep, Zocam, Zolax, Zolorel, Zolyde, Zopax

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Colcrys, Lamisil, Keflex, Mellaril, Aurogra, Terramycin, Hydrea, Mestinon, Celebrex, Mycofem, Gapin, Versamid, Azifast, Julax, Lindan, Lemar,

Also known as: Alprazolam


Plaxid XR (alprazolam) is in a group of drugs called benzodiazepines (ben-zoe-dye-AZE-eh-peens). Alprazolam affects chemicals in the brain that may become unbalanced and cause anxiety.

Plaxid XR is used to treat anxiety disorders, panic disorders, and anxiety caused by depression.

Plaxid XR may also be used for other purposes not listed in this medication guide.


This section provides information on the proper use of a number of products that contain alprazolam. It may not be specific to Plaxid XR. Please read with care.

Take this medicine only as directed by your doctor. Do not take more of it, do not take it more often, and do not take it for a longer time than your doctor ordered. If too much of this medicine is used for a long time, it may become habit-forming (causing mental or physical dependence) or cause an overdose.

This medicine should come with a Medication Guide. Read and follow the instructions carefully. Ask your doctor if you have any questions.

Swallow the extended-release tablet or tablet whole with a full glass of water. Do not break, crush, or chew it.

If you are using the orally disintegrating tablet, make sure your hands are dry before you handle the tablet. Do not remove the tablets from the bottle until you are ready to take it. Place the tablet immediately on the top of your tongue. It should melt quickly and be swallowed with saliva.

If you are using the oral liquid, measure the dose with a marked measuring spoon, oral syringe, or medicine cup.

Do not eat grapefruit or drink grapefruit juice while you are using this medicine.

The dose of this medicine will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of this medicine. If your dose is different, do not change it unless your doctor tells you to do so.

The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.

For anxiety: For oral dosage forms (solution, tablets, or orally disintegrating tablets): Adults—At first, 0.25 to 0.5 milligram (mg) 3 times a day. Your doctor may increase your dose as needed. However, the dose is usually not more than 4 mg per day. Older adults—At first, 0.25 mg 2 or 3 times a day. Your doctor may increase your dose as needed. Children—Use and dose must be determined by your doctor. For panic disorder: For oral dosage form (extended-release tablets): Adults—At first, 0.5 to 1 milligram (mg) taken in the morning once a day. Your doctor may increase your dose as needed. However, the dose is usually not more than 10 mg per day. Older adults—At first, 0.5 mg taken in the morning once a day. Your doctor may increase your dose as needed. Children—Use and dose must be determined by your doctor. For oral dosage forms (solution, tablets, or orally disintegrating tablets): Adults—At first, 0.5 milligram (mg) 3 times a day. Your doctor may increase your dose as needed. However, the dose is usually not more than 10 mg per day. Older adults—At first, 0.25 mg 2 or 3 times a day. Your doctor may increase your dose as needed. Children—Use and dose must be determined by your doctor.


Seek emergency medical attention or call the Poison Help line at 1-800-222-1222. An overdose of alprazolam can be fatal.

Overdose symptoms may include extreme drowsiness, confusion, muscle weakness, loss of balance or coordination, feeling light-headed, and fainting.


Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing.

Keep out of the reach of children.

Do not keep outdated medicine or medicine no longer needed.

Ask your healthcare professional how you should dispose of any medicine you do not use.

It is very important to protect the orally disintegrating tablets from moisture. Remove and throw away any cotton packaging from the medicine bottle when you first use the medicine.

Detailed Plaxid dosage information

Side effects

The most common side effects associated with Plaxid are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.


Appropriate studies performed to date have not demonstrated geriatric-specific problems that would limit the usefulness of alprazolam in the elderly. However, elderly patients are more likely to have unwanted effects (eg, severe drowsiness, dizziness, confusion, clumsiness, or unsteadiness) and kidney, liver, or lung problems, which may require caution and an adjustment in the dose for patients receiving this medicine.

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A major issue is the inability to standardize treatment protocols due to variations in materials and approaches used to accomplish ACL reconstruction. Adequate measurement of the temperature distribution achieved with the hyperthermia is a key element in successful therapy. The early development of secondary sexual characteristics in girls attracts older and more deviant peers, raising probability of sexual contacts but also of drug use and of a disengagement in school activities. Furthermore, the high frequency of the small-vessel stroke subtype in AS patients indicates that small-vessel inflammation may be involved in the pathogenesis of vascular diseases in AS patients. A total of 96 idiopathic infertile male patients and 100 normal fertile men (controls) were included in the study. Dissociation between Low Vitamin D Level and Hypertension in Coal Mine Workers: Evidence from the Kailuan Study. Diagnostic accuracy of the use of parental-reported sleep bruxism in a polysomnographic study in children. A complex interaction that involves multiple biologic and socioeconomic factors appears to predispose young women to this devastating childbirth injury. To better interpret the neuroanatomical pattern of this previous finding and to assess the influence of methodological heterogeneity, we here applied tractography to the same sample. Children enrolled in EPE schools with high OSP have the highest odds of injury and a high probability of sustaining a higher injury count compared to their peers at schools with normal PE.

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Chi-square test was used to determine associations between categorical variables. These results suggest that the Ycks act upstream or at the level of the glucose sensors. In immunized mice, specific anti-HPV16-L1 antibodies could be detected by immunospot and immunocytochemistry 28 days after the first immunization and last at least 41 days. This model is uniquely useful for investigating the normal functional characteristics of several neuroendocrine and endocrine systems. Hidradenoma masquerading digital ganglion cyst: A rare phenomenon. The mechanism of the LTP at marrow level is interpreted through two physiological hypotheses concerning the circuit of Renshaw. Significant differences are found in similar and cross coupling frequency components in all three trimesters and postpartum. We found that, although mouse NPC1 (mNPC1) and hNPC2 co-localize with AP-3 to a similar extent in fibroblasts, hNPC2 preferentially co-localizes with AP-1.

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Skin penetration from the inverted bicontinuous mesophase and the skin penetration from the O/W-like microstructure were higher than that measured from the W/O-like droplets, especially when the micellar system containing the nonionic surfactant, sugar ester L-1695, and hexaglycerol laurate. In two separate experiments, one involving normal rats, and the other involving elastase-treated rats, there was up to a 9-fold increase in REs content in the lungs of rats that received RA or RAG for 12 days as compared to Control rats. A case of Coenurus cerebralis involving both cerebral hemispheres and the interpeduncular cistern is presented to illustrate the computed tomography (CT) and magnetic resonance imaging (MRI) features. This circumstance, which is intrinsic to the very nature of Kerr propagation, was previously discarded on the basis of the conjecture that a reduced system is possible in which only one transverse field component interacts with the longitudinal component. Descriptive, cross-sectional, secondary analysis of a larger study. The MDP-based one-step adhesive yielded several types of MDP-Ca salts and DCPD with an amorphous phase during the 30-s application period on enamel and dentin. Some Statistical Needs for Proper Administration of Maternal and Child Health Programs. Moreover, G0s2 protein content is increased in the livers of high-fat diet (HFD)-fed rats.

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Significant advances have been made with respect to IFN-induced signal transduction pathways and antiviral responses. Sclerostin, encoded by the SOST gene, is a Wnt inhibitor that regulates bone mineralization and is a candidate gene locus for osteoporosis. Thus, central components of the stress response are timed through Tpo1-controlled polyamine export. This study is trying to assess the effects of these recommendations on respiratory tract infections. This review describes the theoretical aspects of SWAP, highlights current limitations associated with the technique and discusses potential clinical applications. Ondansetron is often used in the emergency department (ED) to promote oral rehydration in children with acute gastroenteritis (AGE), yet medication solutions administered orally may be poorly tolerated in this population. This review assesses the literature surrounding the use of the ACE inhibitor perindopril in patients with hypertension and varying degrees of insulin resistance, including the effects of perindopril in preventing the development of diabetes and subsequent cardiovascular morbidity and mortality. With some alterations the European Brain Injury Questionnaire seems to be a useful instrument in clinical practice and research, and a help to capture the social, emotional, and cognitive impacts of a stroke. Our results show that in malignant tissue a transcriptional down-regulation of FECH occurs, which causes endogenous PpIX accumulation. Botulinum Toxin type A can give temporary symptomatic relief in many instances of bothersome diplopia irrespective of the cause.

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This release reaction proceeded temperature-dependently and in a dose-dependent manner between the virion and membrane fractions, and was specific for HIV-1 Env and CD4. The aim of the study was to evaluate the natural history and outcome of patients with sICAD treated medically. Cases in which HER2 copy number gain is not corroborated by genomic analysis suggest the presence of other contributing variables influencing ISH results. Validation of a PCR-oligochromatography test for detection of Trypanozoon parasites in a multicenter collaborative trial. Prediction of 2 years-survival in patients with stage I and II non-small cell lung cancer utilizing (18)F-FDG PET/CT SUV quantification. In the investigated pH region, the highest protonation rate of the monolayers is observed at pH 3.

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Delay in diagnosis was defined as greater than 2.5 months from first ER visit for non-specific back pain to diagnosis of osteomyelitis without antibiotic treatment in the interim. Electrical stimulation of the lateral (LA) and basolateral (BLA) nuclei evoked a large monosynaptic glutamatergic response followed by a disynaptic inhibitory postsynaptic potential. To assess the inequity in seeking needed outpatient services in Iran and to investigate its influential factors. Graduated compression elastic stockings are of no benefit in reducing the incidence of maternal hypotension during caesarean section. Mode of action of taurine and regulation dynamics of its synthesis in the CNS. Our findings indicate that predicting performance needs to take into account in addition to sleep loss, the attentional demands and novelty of tasks, the motion environment in which individuals will be performing and their prior susceptibility to motion sickness during exposure to provocative motion stimulation. We measured IGF-I using an automated chemiluminescent method, IGF-II and IGFBP-2 using in-house radioimmunoassays (RIAs), and IGFBP-1 and IGFBP-3 using commercial enzyme-linked immunosorbent assay (ELISA) and RIA kits, respectively. How surrogate outcomes represented hazard ratios (HRs) for OS was examined. Administration of capsaicin to newborn rats results in a loss of a large percentage of primary afferent C fibers many of which terminate in the substantia gelatinosa (SG). This difference was slightly more apparent in the girls and may be related to brain asymmetry in neuroimmunomodulation.

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Further studies are required to establish the differences between canine reproductive physiology and that of other mammals. Effect of solvents and methods of stirring in extraction of lycopene, oleoresin and fatty acids from over-ripe tomato. Concise review: Sowing the seeds of a fruitful harvest: hematopoietic stem cell mobilization. Phlebiakauranol aldehyde and the corresponding alcohol were isolated from cultures of Punctularia atropurpurascens. We conducted a prospective multicentric study using the European Organization for Research and Treatment of Cancer (EORTC) QLQ-INFO25 and QLQ-C30 questionnaires before and after surgery. We found no evidence for temporal changes in the incremental mortality risk associated with DM in the setting of MI. Both enniatins were poorly absorbed after oral administration, with absolute oral bioavailabilities of 0.05 and 0.11 for ENNs B1 and B, respectively. APROPOS OF THE DEVELOPMENT OF THE SULFONAMIDE INDUSTRY IN THE USSR.

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For the indications and execution of this imaging modality a number of restrictions and safety measures have to be considered. Preclinical medical students who had not received any training in open or laparoscopic surgery were included in this investigation. Samples examined in NSP and SP cohorts were comparable in terms of basic clinical characteristics, median tumour diameter, and distribution of histopathological diagnostic categories. Tracing horizontal Wolbachia movements among bees (Anthophila): a combined approach using multilocus sequence typing data and host phylogeny. Insertion of an intein gene into the active site of the RB69 DNA polymerase gene renders polymerase activity and phage viability dependent on protein splicing. Because nurses and physicians in health care settings may be the first to encounter undiagnosed cases of Chagas disease, it is essential that public health personnel and health care providers in general become more familiar with the disease, including its incidence and prevalence, clinical manifestations, diagnostic criteria, treatment options, and implications for nursing. The purpose of this study was first to evaluate the effect of multipurpose contact lens care solutions (MPSs) on the expression of membrane-associated mucins (MUC1 and MUC16) in SV40-transformed human corneal epithelial (HCE-T) cells and in vivo rat cornea. Efficient transformation of Amycolatopsis orientalis (Nocardia orientalis) protoplasts by Streptomyces plasmids.

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In the age group up to 15 years, age at onset was significantly earlier in the cozaar mg urban than in the rural cases. Angiogenesis plays an essential role in embryo development, tissue repair, inflammatory diseases, and tumor growth. Seven hours after injection, the observed aqueous and vitreous levels of acyclovir were above the minimum inhibitory concentrations for many herpes simplex viruses types 1 and 2. EPISOME-MEDIATED TRANSFER OF DRUG RESISTANCE IN ENTEROBACTERIACEAE. BASE-LINE VALUES FOR AN INTRAMUSCULAR ACTH TEST BASED ON PAROTID FLUID FREE 17-HYDROXYCORTICOSTEROID LEVELS. The fourth-passage cells were used to investigate the effect of dexamethasone on the tight junctions in rat retinal vascular endothelial cells. However, its diagnosis can easily be overlooked, especially by clinicians who are unfamiliar with this pathology. We report a case of autochthonous falciparum malaria in a patient in Paris, France, in February 2013 who reported no recent travel to malaria-endemic countries. Our findings suggest that eNOS and nNOS display functional overlap in the newborn mouse gastrointestinal tract and that simultaneous reduction in the activity of both NOS isoforms may be a risk factor for neonatal ileal perforation. Flow alteration techniques leading to aneurismal thrombosis carried the risks of ischemic and hemorrhagic complications when applied to intracranial aneurysms.

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ANDROGEN-INDUCED REVERSAL OF PARENTAL BEHAVIOUR IN THE FEMALE RABBIT. This methodology enabled quick and cost-efficient collection of data about hospital eye services, the conditions diagnosed and treated, and the outcome of treatment. Use of TID resulted in no early major complications and only 2 glucophage xr dosing early minor complications. The doses of 50 micrograms FK506 are proved to be toxic to the retina. Partial least-squares (PLS) calibration models are generated for each component, and these models provide selective responses for the targeted analytes with standard errors of prediction ranging from 0.2 to 0.7 mM over the concentration range of 0.5-50 mM. THE VALUE OF THE PUBLIC HEALTH NURSE IN PUBLIC HEALTH AND WELFARE ADMINISTRATION. Circular dichroism (CD) spectroscopy has been a valuable method for the analysis of protein secondary structures for many years. A 9-item knowledge questionnaire was employed immediately following an informed choice invitation to type 2 diabetes screening that was piloted with 278 people between 40 and 69 years in the U.K.

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Finally we suggest VAI RNA functions through a direct interaction with the P68 protein kinase, since we demonstrated that VAI RNA forms a complex with P68 both in vitro and in vivo. Numerous studies aimed at developing novel miRNA-based drugs or determining miRNA functions have been conducted by inhibiting miRNAs using anti-miRNA oligonucleotides (AMOs), which inhibit the function by hybridizing with miRNA. This tumor, while histologically benign, can cause fatal cardiovascular symptoms resulting from growth within the heart cavity. Dehydroepiandrosterone sulphate, testosterone and oestradiol levels all decreased and tended to return to baseline levels during the observation period. Gentamicin-loaded plaster of Paris as a treatment of experimental osteomyelitis in rabbits. This study was designed to evaluate the effectiveness of Stenger test and acoustic reflexes test (ART) in the evaluation of patients with suspicious of unilateral NOHL. In this study, we investigated the mechanism of ceramide-induced apoptosis in primary rat oligodendrocytes. infantis ATCC 15697 within the human gut microbiota using alginate-poly-L-lysine-alginate microencapsulation oral delivery system: an in vitro analysis using a computer-controlled dynamic allegra d 120 mg dosage human gastrointestinal model.

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Evaluating minimalist mimics by exploring key orientations on secondary structures (EKOS). MCM10 protein is an essential replication factor involved in the initiation of DNA replication. This paper demonstrates tremor compensation for human subjects using an active handheld micromanipulator. To systematically review and meta-analyze studies evaluating the effect of age at onset of menopause and duration since onset of menopause on intermediate CVD end points, CVD outcomes, and all-cause mortality. To study whether lactulose or polyethylene glycol is effective to promote defecation in critically ill patients, whether either of the two is superior, and whether the use of enteral laxatives is related to clinical outcome. The association between serum folate concentration and BP has been examined in few studies. phagocytophilum isolates share the ability to use sLe(x)-modified PSGL-1-dependent and -independent routes of entry elavil medication pain into myeloid cells. In subsequent extinctions, the CRF schedule produced more responses on the first day than did VI, but after the first day the post-CRF rate dropped much more rapidly. Its finding far upstream indicates a strong effect of an as yet unidentified stress along the Sava River up to the spot where the bighead goby was sampled. To evaluate the effects of balance retraining in a sample of people with multiple sclerosis.

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Novel theoretical results complemented with existing approaches (LCD re-capture detection and denoising) were implemented in the PIZZARO software tool, which consists of the image processing functionality as well as of reporting and archiving functions to ensure the repeatability of image analysis procedures and thus fulfills formal aspects of the image/video analysis work. High frequency loss of heterozygosity in the region of the DBH locus in bladder cancer. Evolving Health IT Systems Evaluation: The Convergence of Health Informatics and HTA. Reporting of adherence to medication in recent randomized controlled trials of 6 chronic diseases: a systematic literature review. Bioinformatic analysis suggests that cell adhesion, immune response, glycoprotein metabolic process, cell motion, and cell activation were associated with the changed proteins. In the era of novel therapies, ASCT remains commonly used and its impact on outcome appears superior, albeit less so than when compared with conventional therapy, and its survival benefit is yet to be established in either setting. Rewarming the severely hypothermic patient with the help of heart-lung machine.

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In addition, we provide algorithms for the calculation of the angular distance between the gaze and a relevant virtual object and for the identification of fixations, saccades, and pursuit eye movements. This enzyme leakage was suppressed dose-dependently by TRQ at 42 hr, but not by vitamin E. Clinical responses were present in all patients, but the largest gains occurred in patients with advanced disease receiving high-dose rhASB. Taking in sufficient quantities of nutrients is vital for all living beings and in doing so, individuals interact with the local resource environment. In situ mechanical behavior of posterior spinal ligaments in the lumbar region. Tacrolimus levels, urinary cultures, and renal function tests were done as per unit protocol. With the exception of the Ruminococcus sequences, sequences originating from both rats and human samples were represented in all major branches of a maximum parsimony tree, indicating that the rat feed and gut environment allows colonization of the dominant taxonomic units from the human microbiota, but additionally selects for Ruminococci. Risk factors for infection and catching tuberculosis in adolescents in relation to the epidemic risk of a tuberculous focus. Hirudin is a specific polypeptide thrombin inhibitor consisting of 65 amino acids that is produced by the leech, Hirudo medicinalis. Iron effects on colonization behavior, motility, and enzymatic activity of marine bacteria.

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